[关键词]
[摘要]
滇桂艾纳香为壮医常用妇科产后止血药材,疗效好,临床应用广泛。滇桂艾纳香的质量标准不够完善,随着近年化学成分和药理活性研究不断深入,使其质量标志物(quality marker,Q-Marker)的预测成为可能。对滇桂艾纳香进行本草考证、化学成分和主要药理活性总结,并在此基础上结合Q-Marker的核心概念,从化学成分特有性、有效性、可测性和可入血成分方面对滇桂艾纳香Q-Marker进行预测分析,可推测滇桂艾纳香中异绿原酸A、异绿原酸B、异绿原酸C的含量比例或许可作为滇桂艾纳香化学成分特异性不足的Q-Marker专属性补充,为其质量评价提供了理论依据。
[Key word]
[Abstract]
Blumeae Ripariae Herba is a tradional Zhuang herb with wide clinical application, which has significantly therapeutic effect and commonly used for gynecology postpartum hemostatic. Although the quality standard of Blumeae Ripariae Herba should be improved, but numerous studies of chemical constituents and pharmacological activities in recent years makes it possible to predict its Q-Marker. In this paper, textual research, chemical constituents and main pharmacological activities of Blumeae Ripariae Herba were summarized, then combined with the core concept of Q-Marker, the Q-Markers of Blumeae Ripariae Herba basis were analyzed and predicted from the aspects of the specificity, effectiveness and measurability of chemical components, and blood entry components, It can be speculated that the content ratio of isochlorogenic acid A, isochlorogenic acid B, and isochlorogenic acid C may be used as a Q-Marker exclusive supplement for the lack of specificity of chemical components in Blumeae Ripariae Herba, in order to provide a theoretical basis for its quality evaluation.
[中图分类号]
R282.6
[基金项目]
国家重点研发计划项目(2018YFC1708005);四川省科技计划项目(重点研发项目)(2021YFS0043);西南民族大学中央高校基本科研业务费专项资助(2020NGD01)