“逢子必炒”是种子类中药临床用药经验的总结，是中药炮制理论的重要组成部分，蕴含着丰富的科学内涵。传统认为种子类中药炒制的目的主要包括增效减毒、缓性以及祛除非药用部位等。现代研究发现，种子类中药炒制后对于成分的溶出、主要成分结构变化、成分的体内吸收和毒效作用等均具有一定的影响，这些研究成果对于阐明种子类中药“逢子必炒”的科学内涵具有指导意义，为种子类中药炮制机制研究奠定了基础。提出开展“逢子必炒”炮制机制研究的思路和方法，为种子类中药炮制机制研究提供借鉴。

“Seed drugs be stir-fried” is an important part of the processing theory of traditional Chinese medicine. It is a summary of the clinical medication experience of seed traditional Chinese medicine and contains the rich scientific connotation. Traditionally, the purpose of frying seed traditional Chinese medicine includes increasing efficiency, reducing toxicity and slowing down drug properties, and removing non medicinal parts. Modern studies have found that the frying of seed traditional Chinese medicine has a certain impact on the dissolution of components, structural changes of main components, in vivo absorption and toxic effects of components. These research results have guiding significance for clarifying the scientific connotation of “seed drugs be stir-fried” of seed traditional Chinese medicine, and have laid a foundation for the research on the processing mechanism of seed traditional Chinese medicine. This paper puts forward the ideas and methods of the research on the processing mechanism of “seed drugs be stir-fried”, which provides a reference for the research on the processing mechanism of seed traditional Chinese medicine.

R283.1

国家自然科学基金项目(81573603);国家自然科学基金项目(81603297);江苏省高校自然科学研究重大项目(21KJA360005);江苏省中医药局科技项目(YB2020109)