花旗松素是一种黄酮类化合物，常见于多种植物和蔬菜中。诸多研究者很久之前就已经开始从植物中提取并纯化花旗松素，常用的提取试剂为乙醇溶液，提取方法为加热回流提法、酶提取及超声提法等；在纯化操作中，包含吸附、洗脱和重结晶等诸多繁琐步骤。因结构优势，花旗松素具有强效的抗氧化活性，多种研究证实花旗松素具有效果良好的抗炎作用、肝脏和心血管保护作用、抗痴呆活性及抗癌作用等。因此，结合已报道的广泛药理作用研究，对花旗松素的植物来源及相关提取纯化方法进行系统归纳和总结，以期为花旗松素的研发和药用价值提供较为全面的参考。

Taxifolin is a flavonoid that can be commonly found in a diversity of plants and vegetables. It has been extracted and purified from plants by several research workers for a long time. The typical used extraction reagents are ethanolic solutions, and the extraction methods are heating reflux extraction, enzymatic extraction and ultrasonic extraction. The purification operation involves many tedious steps such as adsorption, elution and recrystallisation. Due to its structural advantages, taxifolin has potent antioxidant activity, and considerable previous studies have confirmed that taxifolin has effective anti-inflammatory action, hepatic and cardiovascular protective function, anti-dementia activity and notably therapeutic effect on cancer cells. According to the already reported pharmacological activities, research progress on taxifolin in terms of its origin, extraction, purificationare summarized in this paper, in order to provide a more comprehensive reference for the development and pharmaceutical value of taxifolin.

R282.710.5

国家重大新药创制科技重大专项(2017ZX09031062);天津市"项目+团队"重点培养专项(创新类)(XC202030);中国医学科学院医学与健康科技创新工程项目资助(2019-I2M-5-020)