目的 对披针叶茴香Illicium lanceolatum果实的化学成分进行研究。方法 采用正相硅胶、MCI gel、RP-C₁₈、Sephadex LH-20、HPLC等多种色谱技术进行分离纯化,根据波谱数据鉴定化合物的结构。并对化合物进行神经保护活性评价。结果 从披针叶茴香果实95%乙醇提取物中分离得到15个化合物,包括4个异戊烯基取代C₆-C₃类、3个苯丙素类、1个苯乙醇苷类、5个seco-prezizanne倍半萜类、2个脱落酸衍生物,分别鉴定为披针叶茴香酮A(1)、illioliganone C(2)、2-allyl-2-(3-methylbut- 2-enyl)-4,5-methylenedioxy-cyclohexa-3,5-dien-1-one(3)、4-allyl-2,6-dimethoxy-3-(3-methyl-2-butenyl)phenol(4)、3,4'-二羟基苯丙酮(5)、2,6-二甲氧基-4-烯丙基苯酚(6)、3,4'-二羟基苯丙酮-3-O-β-D-吡喃葡萄糖苷(7)、苯乙醇-O-β-D-吡喃葡萄糖苷(8)、2α-羟基莽草毒素(9)、2α-羟基新莽草毒素(10)、新莽草毒素(11)、莽草毒素(12)、2-氧代-6-去羟基新莽草素(13)、rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid(14)、红花菜豆酸(15)。结论 化合物1为新化合物,无明显神经保护活性;化合物5、7、8为首次从该属植物中发现,化合物2~8、11、13~15为首次从该植物中分离得到。

Objective To study the chemical constituents from the fruits of Illicium lanceolatum. Methods The chemical constituents were isolated and purified by column chromatography on silica gel, MCI gel, RP-C₁₈, Sephadex LH-20, and HPLC. Their structures were elucidated on the basis of spectroscopic data. Results Fifteen compounds including four prenylated C₆-C₃ compounds, three phenylpropanoids, one phenylethanol glycoside, five seco-prezizanne sesquiterpenes, and two abscisic acid derivatives were isolated from 95% ethanol aqueous extract of I. lanceolatum, and the structures were identified as illancinone A (1), illioliganone C (2), 2-allyl-2-(3-methylbut-2-enyl)-4,5-methylenedioxy-cyclohexa-3,5-dien-1-one (3), 4-allyl-2,6-dimethoxy-3- (3-methyl-2-butenyl)phenol (4), 3,4'-dihydroxy-propiophenone (5), 2,6-dimethoxy 4-allylphenol (6), 3,4'-dihydroxy-propiophenone- 3-O-β-D-glucopyranoside (7), phenylethyl-O-β-D-glucopyranoside (8), 2α-hydroxyanisatin (9), 2α-hydroxyneoanisatin (10), neoanisatin (11), anisatin (12), 2-oxo-6-dehydroxyneoanisatin (13), rel-5-(3S,8S-dihydroxy-1R,5S-dimethyl-7-oxa-6-oxobicyclo[3,2,1]-oct-8-yl)-3-methyl-2Z,4E-pentadienoic acid (14) and phaseic acid (15). Conclusion Compound 1 is a new compound named illancinone A, compounds 5, 7, and 8 are isolated from Illicium genus for the first time, and compounds 2-8, 11, and 13-15 are isolated from this plant for the first time.

云南省创新团队（202005AE160004）；云南省科技厅-昆明医科大学应用基础研究联合专项基金（2019FE001-028）；云南省万人计划“教学名师”（宋流东）资助项目；云南省万人计划“青年拔尖人才”资助项目（吴兴德）