[关键词]
[摘要]
目的 基于网络药理学探究丹红化瘀口服液治疗视网膜静脉中央阻塞症的作用机制。方法 选取丹红化瘀口服液中的21个入血成分为研究对象,借助TCMSP和CTD数据库预测化合物的作用靶点,利用MAS 3.0生物分子功能软件获取相关通路,通过FUNRICH软件对获得靶点进行基因本体(gene ontology,GO)功能富集分析,最后利用Cytoscape软件构建"化合物-靶点-通路-疾病"网络图。结果 21个成分可作用于104个蛋白靶点和45条通路,其中多个靶点和通路与视网膜静脉中央阻塞症相关。结论 丹红化瘀口服液通过作用于与凝血过程、新血管生成、血管舒张、免疫调节和炎症反应等相关的靶点,起到活血化瘀、行气通络的功效,从而治疗视网膜中央静脉阻塞症。
[Key word]
[Abstract]
Objective To study the mechanisms of Danhong Huayu Oral Liquid (丹红化瘀口服液) in the treatment of central retinal vein occlusion (CRVO) by network pharmacology. Methods Twenty-one components absorbed into blood of Danhong Huayu Oral Liquid were selected as objects, targets were explored by TCMSP and CTD database and related pathways were obtained by MAS 3.0 software. The gene ontology (GO) functional analysis were explored by FUNRICH software. Finally, the network of "compound-target-pathway-disease" of Danhong Huayu Oral Liquid was constructed by Cytoscape software. Results Twenty-one components of Danhong Huayu Oral Liquid affected 45 pathways through 104 target proteins which were related to CRVO. Conclusion Danhong Huayu Oral Liquid has the effect of promoting blood circulation and removing blood stasis, invigorating qi and activating collaterals through acting on the targets related to coagulation process, neovascularization, vasodilation, immune regulation and inflammatory reaction, thereby treating CRVO.
[中图分类号]
R285.5
[基金项目]
广州市珠江科技新星专项资助（201806010082）；中国医学科学院医学与健康科技创新工程项目资助（2019-I2M-5-020）；广州市科学技术协会2019年“广州市院士专家工作站”建设项目资助（600180）
