余甘子为大戟科植物余甘子Phyllanthus emblica的干燥成熟果实。对余甘子化学成分及主要药理作用进行综合分析，基于中药质量标志物（quality marker，Q-Marker）理论，对余甘子从传统药性、药效、药效物质基础和化学成分可测性的角度进行Q-Marker初步预测。基于文献整合及数据分析对余甘子Q-Marker的来源范围进行筛选，通过网络药理学进行成分有效性分析，酚酸类及黄酮类成分中木犀草素、槲皮素、山柰酚、(−)-表没食子儿茶素-3-没食子酸酯等化合物可作为余甘子的主要Q-Marker，为其整体质量控制提供参考依据。

Yuganzi (Phyllanthi Fructus) is the dry mature fruit of Phyllanthus emblica in Euphorbiaceae. Chemical composition and main pharmacological activities of P. emblica were summarized in this paper, based on quality marker (Q-Marker) theory of traditional Chinese medicine, Q-Marker of P. emblica was predicted and analyzed from the perspective of traditional medicinal property and efficacy, chemical composition effectiveness and measurability. Based on literature integration and data analysis, Q-Marker source range of P. emblica was screened, and the effectiveness of components of P. emblica was further confirmed through network pharmacology. Phenolic acids and luteolin, quercetin, kaempferol, and (−)-epigallocatechin-3-gallate in flavonoids can be used as the main Q-Markers of P. emblica, in order to provide reference for the whole quality control of P. emblica.

R282.710.5

2017年广西中药药效研究重点实验室（17-259-20）；广西中医药大学2020年研究生教育创新计划项目（YCSZ2020008）；广西高等学校高水平创新团队及卓越学者计划项目（2019-52）