沉香为名贵药材和香料，倍半萜类化合物是沉香的特征成分和主要活性成分，根据其分子骨架可将沉香倍半萜类化合物分为8类。系统地总结了从沉香中分离出的倍半萜类化合物，并对其调节中枢神经系统、抗炎、抗肿瘤细胞毒、抑菌等活性的研究现状进行综述，并在此基础上结合质量标志物（quality marker，Q-Marker）的核心概念，从生源途径、传统药效、传统药性和化学成分等方面对沉香的Q-Marker进行预测分析，α-沉香呋喃、β-沉香呋喃、沉香螺旋醇可作为沉香的Q-Marker，为建立和完善沉香质量标准提供依据，以期为沉香质量的深入研究提供参考。

Chenxiang (Aquilariae Lignum Resinatum) is a precious medicinal material and spice. Sesquiterpenoids are the characteristic components and main active ingredients of it. According to their molecular skeleton, the sesquiterpenoids contained in Aquilariae Lignum Resinatum could be divided into eight categories. Sesquiterpenoids isolated from Aquilariae Lignum Resinatum and research status of central nervous system activity, anti-tumor cytotoxic activity, antibacterial activity, anti-inflammatory activity and other biological activities were reviewed in this paper. And on the basis of the above, combined with the core concept of quality marker (Q-Marker), Q-Markers of Aquilariae Lignum Resinatum were predicted and analyzed and analyzed from the aspects of biogenic pathway, traditional medicine, traditional properties, and chemical composition. α-Agarofuran, β-agarofuran, and agarospirol can be used as the main Q-Markers of Aquilariae Lignum Resinatum, which provide a basis for establishing and improving the quality standards of Aquilariae Lignum Resinatum and for further research and development of Aquilariae Lignum Resinatum.

R282.710.5

国家重点研发计划项目（2018YFC1706403）；海南省重点研发计划项目（ZDYF2020111）