目的 观察甜梦口服液联合文拉法辛治疗脾肾阳虚型抑郁症的疗效。方法 选择2017年9月—2018年9月就诊于唐山市工人医院脾肾阳虚型抑郁症患者92例，按照随机数字表法分成对照组和治疗组，各46例。对照组患者口服盐酸文拉法辛缓释片及甜梦口服液模拟剂，治疗组患者口服盐酸文拉法辛缓释片及甜梦口服液，疗程为4周。观察2组治疗后临床疗效，比较两组治疗1、2、4周后的汉密顿焦虑量表（Hamilton depression scale，HAMD）、匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）及中医证候评分情况。结果 治疗组的HAMD评分显效率为80.43%，总有效率为95.65%，明显高于对照组的60.87%、89.13%（P<0.05）；PSQI评分在治疗1周及4周后，与治疗前相比，治疗组PSQI评分显著降低（P<0.05），且明显低于对照组（P<0.05）。结论 甜梦口服液联合文拉法辛治疗脾肾阳虚型抑郁症疗效明显且优于单用文拉法辛，且治疗过程中无明显的不良反应发生，证实甜梦口服液在抑郁症治疗中作用显著。

Objective To observe the clinical effect of Tianmeng Oral Liquid (甜梦口服液) combined with Venlafaxine in treating depression of spleen and kidney yang deficiency.Methods A total of 92 patients with depression of spleen and kidney yang deficiency in Tangshan Workers Hospital from September 2017 to September 2018 were selected and divided into control group and treatment group according to random number table method, with 46 cases in each group. The patients in the control group were treated with Venlafaxine Hydrochloride Sustained Release Tablets and Tianmeng Oral Liquid simulant, while the patients in the treatment group were treated with Venlafaxine Hydrochloride Sustained Release Tablets and Tianmeng Oral Liquid, the course of treatment was four weeks. The clinical efficacy of the two groups after treatment were observed, and the Hamilton depression scale (HAMD), Pittsburgh sleep quality index (RSQI), and Chinese medicine syndrome score were compared between the two groups one, two and four weeks after treatment. Results The significant efficiency of the HAMD score in the treatment group was 80.43%, and the total effective rate was 95.65%, which was significantly higher than the 60.87% and 89.13% in the control group. The PSQI score after 1 and 4 weeks of treatment was significantly lower than that before treatment (P < 0.05), and significantly lower than that in the control group (P < 0.05). Conclusion The efficacy of Tianmeng Oral Liquid combined Venlafaxine in the treatment of depression with spleen and kidney yang deficiency is obviously better than that of Venlafaxine alone, and no obvious adverse reactions in the treatment process, confirming that Tianmeng Oral Liquid has a significant effect in the treatment of depression.

R285.64