糖尿病是一种血糖水平异常增高的内分泌系统疾病，糖尿病及其并发症的流行已经对全球健康构成了重大威胁。灵芝Ganoderma是我国珍贵的传统中药材，而灵芝多糖是灵芝的主要有效成分之一，具有多种药理作用，包括抗肿瘤、提高免疫、抗肥胖及降血糖等。就灵芝多糖对糖尿病的作用及分子机制，重点是灵芝多糖对改善糖尿病并发症的研究进展进行综述，包括糖尿病肾病、糖尿病相关心脏疾病、糖尿病神经病变及糖尿病足，并阐明其可能的分子作用机制。从多方面为灵芝多糖抗糖尿病及其并发症的基础研究及临床应用提供理论依据。

Diabetes is an endocrine system disease with abnormally high blood sugar levels. The prevalence of diabetes and its complications has posed a major threat to global health. Lingzhi (Ganoderma) is a precious traditional Chinese medicine (TCM) in China. Ganoderma polysaccharide is one of the main bioactive compounds of Ganoderma. It has a variety of pharmacological effects, including antitumor, immune regulation, anti-obesity and blood glucose lowering effects. In this review, the anti-diabetic role and the underlying molecular mechanisms of Ganoderma polysaccharide from the literatures were reviewed for the first time. The progress of Ganoderma polysaccharide in improving diabetes complications were focused on, including diabetic kidney disease, diabetic heart disease, diabetic neuropathy and diabetic foot, and its possible molecular mechanisms was clarified. This review will provide theoretical basis for the laboratory studies and clinical application of Ganoderma polysaccharide in diabetes and its complications therapy from a broad aspect.

R285

国家自然科学基金项目（81973521）；浙江省重点研发计划项目（2019C02100）