目的 研究复方蜥蜴散在大鼠体内的代谢产物。方法 大鼠ig复方蜥蜴散后，收集并处理血浆、胆汁、尿液、粪便，采用UHPLC-LTQ-Orbitrap-MS方法以及质量亏损过滤技术分析主要成分代谢产物。结果 建立了复方蜥蜴散代谢产物分析方法，共鉴定出芒柄花素、毛蕊异黄酮、延胡索乙素等8个原型成分和31个代谢产物。结论 复方蜥蜴散主要成分在大鼠体内主要发生去甲基化、羟基化、还原反应等I相反应，硫酸化、葡萄糖醛酸化等II相反应，所建立的方法简单可靠。为进一步阐明复方蜥蜴散药效物质基础，优化临床给药方案提供依据。

Objective To study the metabolites of Compound Xiyi Powder (复方蜥蜴散) in rats. Methods After rats ig administrated with Compound Xiyi Powder, the plasma, bile, urine and feces were collected and disposed. The main metabolites were analyzed by UHPLC-LTQ-Orbitrap-MS method and quality loss filtering technology. Results A method for the analysis of metabolites of Compound Xiyi Powder was established, and eight prototype components and 31 metabolites were identified, including. formononetin, calycosin, tetrahydropalmatine and so on. Conclusion The main components of the prescription mainly occurred in the first phase of demethylation, hydroxylation and reduction, and the second phase of sulfation and glucuronization, the established method is simple and reliable. It provides the basis for further elucidating the material basis of Compound Xiyi Powder and optimizing the clinical drug delivery scheme.

R284.1

宁夏回族自治区重点研发计划（东西部合作）项目（2017BY084）