癌症是一种以细胞代谢重编程为特征的全身性疾病，通过有氧糖酵解的方式消耗葡萄糖并促进肿瘤细胞中生物质的大量合成。中药作为我国传统药材，药效广泛并起到整体治疗的作用。随着对中药的进一步研究，发现部分醌类、酚类、黄酮类、萜类等中药活性成分能够通过靶向糖酵解限速酶丙酮酸激酶M2（pyruvate kinase M2，PKM2）引起不同肿瘤细胞线粒体功能障碍、细胞周期阻滞并干扰糖酵解进程，抑制肿瘤细胞增殖、转移、侵袭等的能力从而发挥显著的抗肿瘤作用。对靶向调控PKM2的紫草素、丹参酮类、白藜芦醇等多种抗肿瘤中药活性成分的作用通路与研究进展进行综述。

Cancer is a systemic disease characterized by cellular metabolic reprogramming, which consumes glucose through aerobic glycolysis and promotes the massive synthesis of biomass in tumor cells. Traditional Chinese medicine is a traditional medicinal material in China, which has a wide range of medicinal effects and has a holistic therapeutic effect. With further research on traditional Chinese medicines, it has been discovered that some active ingredients, such as quinones, phenols, flavonoids, and terpenes could cause mitochondrial dysfunction, cell cycle arrest, glycolysis disorders and down-regulate the ability of tumor cell proliferation, metastasis, invasion, etc. In different tumor cells by targeting the glycolytic rate-limiting enzyme pyruvate kinase M2 (PKM2) to play a significant anti-tumor effect. The pathways and research progress on various anti-tumor Chinese medicine active ingredients such as shikonin, tanshinones, resveratrol, etc., which target and regulate PKM2 are reviewed in this paper.

R282.710.5

国家自然科学基金资助项目（81973528）；辽宁省教育厅科学研究面上项目（LJKZ0907）；沈阳市中青年科技创新人才支持计划（RC210451）