肝癌是临床肝病科较为常见的疾病之一，具有高发病率、高复发率及高致死率。近年来线粒体介导的凋亡途径成为防治肝癌的研究热点，如何更好地利用中医药低毒性、多靶点、多环节的优势通过介导线粒体凋亡途径抑制肝癌的发生发展，仍是临床中急需解决的关键问题。从单味中药、中药复方及中药注射液的分子机制方面综述中药介导线粒体防治肝癌的研究进展，并围绕研究中存在的问题进行讨论和展望。

Liver cancer is one of the most common diseases in clinical hepatology department, which has high incidence, high recurrence rate and high mortality rate. In recent years, mitochondria-mediated apoptosis has become a research hotspot in the prevention and treatment of liver cancer. How to make better use of the advantages of low toxicity, multi-target and multi-link of traditional Chinese medicine to inhibit the occurrence and development of liver cancer by mediating mitochondrial apoptosis is still a key problem to be solved urgently in clinic. In this paper, research progress on mitochondrial prevention and treatment of liver cancer mediated by traditional Chinese medicine is reviewed from the molecular mechanism of single traditional Chinese medicine, traditional Chinese medicine compound and traditional Chinese medicine injection, and the existing problems in the research are discussed and prospected.

R282.710.5

国家中医药管理局全国中医药创新骨干人才培训项目（国中医药人教函[2019]128号）