目的 以玄参 Scrophularia ningpoensis 为研究对象，分析药材中内在化学成分与其法定指标整体间的关联性，探讨以内在成分快速辨别药材品质优劣的可行性。方法 取玄参药材按《 中国药典》 2020 年版一部玄参项下测定，采用等权比值综合评分法对玄参药材进行品质优劣排序，使用色谱指纹图谱筛选共有成分并进行主成分分析，观察药材自然聚集趋势与品质优劣间关系，提出"以成分辨品质"试验假想并进行分析验证。结果 不同来源玄参药材品质存在一定差异，等权综合比值评分法可有效表征玄参药材品质优劣，药材中内在化学成分与法定指标整体间具有一定关联性，验证试验有效。结论 以内在成分含量差异对玄参药材进行品质优劣判别具有一定的可行性，可为玄参及其他部分中药材品质研究提供新思路和参考依据。

Objective To analyze the correlation between the internal chemical components of the medicinal materials and their regulatory indicators by taking Chinese medicinal material Scrophulariae Radix as the research object, and to explore the feasibility of rapidly identifying the quality of the medicinal materials through their internal components. Methods Scrophulariae Radix was used to carry out the identification as directed in Chinese Pharmacopoeia 2020, Scrophulariae Radix. The equal weight ratio comprehensive scoring method was adopted to rank the quality of Scrophulariae Radix medicinal material. Chromatographic fingerprint was used to screen common components and complete the principal component analysis. The relationship between the natural aggregation tendency and the quality of medicinal material was observed and the experimental hypothesis of "identifying quality by components" was proposed and verified. ResultsThere were some differences in the quality of Scrophulariae Radix medicinal material from different sources. Equal weight comprehensive ratio scoring method could effectively characterize the quality of Scrophulariae Radix medicinal material. There was a certain correlation between the internal chemical components of the medicinal materials and their regulatory indicators. The verification was valid. Conclusion It is feasible to judge the quality of Scrophulariae Radix medicinal material based on the difference in the content of the internal ingredients, which can provide new method and reference for the quality research of Scrophulariae Radix and other Chinese medicinal materials.

R286.2

国家中药标准化项目：复方血栓通胶囊标准化建设（ZYBZH-C-GD-06）