[关键词]
[摘要]
目的 研究独子藤Celastrus monospermus茎的化学成分。方法 采用乙醇浸提法进行提取，利用溶剂萃取法和多种柱色谱法进行化合物纯化，并运用波谱学数据鉴定化合物的结构。通过X-射线单晶衍射确定新化合物绝对构型。结果 从独子藤茎中分离鉴定了7个化合物，分别鉴定为3-羰基-11β，12α-二羟基木栓烷（1）、monospermonol（2）、3-羰基-12α-羟基木栓烷（3）、D：A-飞齐墩果-29-醇-3-酮（4）、3-羰基-20α-木栓烷酮酸（5）、23-nor-6-oxodemethylpristimerol（6）、去甲基泽拉木醛（7）。结论 化合物1为新化合物，命名为独子藤素I，化合物7为首次从该属植物分离得到。化合物4~6为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To investigate the chemical constituents from the stems of Celastrus monospermus. Methods The compounds were isolate and purified by ethanol extraction, solvent extraction method and repeated column chromatography. Then the structures of obtained compounds were determined by spectral data analyses. The absolute configuration of new compound was defined via X-ray crystallography. Results Seven compounds were isolated from the stems of C. monospermus and identified as 3-oxo-11β,12α-dihydroxyfriedelane (1), monospermonol (2), 3-oxo-12α-hydroxyfriedelane (3), D:A-friedoolean-1-en-29-ol-3-one (4), 3-oxo-friedelan-20α-carboxylic acid (5), 23-nor-6-oxodemethylpristimerol (6) and demethylzeylasteral (7), respectively. Conclusion Compound 1 is a new friedelane named celasmonolane I. Compound 7 is isolated from the genus of Celastrus for the first time. Compounds 4-6 are separated from this plant for the first time.
[中图分类号]
R284.1
[基金项目]
上海高校教师产学研践习计划（A3-2601-20-311001-8）；上海市卫生健康委员会卫生行业临床研究专项（20184Y0138）；上海市青年科技英才扬帆计划（20YF1418300）；上海市卫生健康委员会卫生行业临床研究专项（20184Y0255）；龙华医院第二批药剂人才培养计划（RC-2020-03-05）
