慢性社交挫败应激抑郁（chronic social defeat stress depression，CSDS）模型是利用生理和心理双重应激使实验动物出现抑郁样状态，进一步以传统抑郁动物模型评价指标及社会交互作用指数进行评价。该模型可以较好地模拟人类在日常的交往活动中因为社交压力过大、频繁的挫败感或长期遭受欺凌而导致的社交挫败抑郁样行为，同时也可以在动物水平的研究中评价药物对于抑郁状态及社会功能的改善作用。主要对CSDS模型的建立方法、评价指标以及在抗抑郁中药研究方面的应用等进行综述，为该模型在社交挫败抑郁疾病发生机制以及抗抑郁药物研发和作用机制研究方面的应用提供支撑。

Chronic social defeat stress depression (CSDS) model is a kind of depression-like state in experimental animals caused by physiological and psychological stress. And it is further evaluated by traditional indexes of depressive state and social interaction ratio. CSDS model can better simulate the depressive behavior caused by excessive social pressure, frequent defeat, or being long-term bullied in human daily communication activities. Meanwhile, the effect of drugs on improvement of depression and social function can also be evaluated in animal-level studies by using this model. In this paper, establishment methods, evaluation indexes, and application of the model in the study on antidepressant effect of traditional Chinese medicine are reviewed, in order to provide important support for the study of pathological mechanism of depression as well as research and mechanism of action of antidepressant drugs.

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国家“重大新药创制”科技重大专项（2017ZX09301047）；国家自然科学基金资助项目（82074147）；山西省科技厅重点研发计划项目（201903D321210）；地产中药功效物质研究与利用山西省重点实验室（202105D121009）