糖尿病心肌病（diabetic cardiomyopathy，DCM）是糖尿病心血管并发症之一，约30%糖尿病患者会出现心功能障碍，并逐渐发展为DCM，最终导致心力衰竭而死亡。核因子E2相关因子2（nuclear factor NF-E2-related factor 2，Nrf2）是治疗DCM的作用靶点之一，在增强心肌抗氧化、抗炎、抗纤维化及抗细胞凋亡能力等方面发挥重要作用。研究表明，多种中药及其有效成分能够通过调控Nrf2信号通路防治DCM。对中药通过Nrf2途径治疗DCM的研究进展进行综述，以期为靶向激动Nrf2的创新中药的开发提供参考。

Diabetic cardiomyopathy (DCM) is one of the cardiovascular complications of diabetes. About 30% of diabetic patients develop heart dysfunction, which gradually develops into DCM, eventually leading to heart failure and death. Nuclear factor NF-E2-related factor (Nrf2) is one of the effective targets for the treatment of DCM. It plays an important role in enhancing the anti-oxidant, anti-inflammatory, anti-fibrosis and anti-apoptotic effects of the myocardium. Studies have shown that several traditional Chinese medicines and their active ingredients can prevent and treat DCM by regulating the Nrf2 signaling pathway. Research progress on traditional Chinese medicine in treatment of DCM through regulating the Nrf2 pathway in recent years are reviewed in this paper, in order to provide a reference for the development of innovative traditional Chinese medicines targeting Nrf2.

R282.710.5

国家重点研发计划“中医药现代化研究”重点专项（2019YFC1708803）；国家自然科学基金重点项目（81830112）；天津市自然科学基金青年项目（20JCQNJC00160）