[关键词]
[摘要]
目的 制备共聚维酮-泊洛沙姆姜黄提取物固体分散体[PVP/VA-Poloxamer-Curcumae Longae Rhizoma extract (CLRE) solid dispersion (SD),PAP-CSD]、共聚维酮姜黄提取物固体分散体(PVP/VA CLRE solid dispersion,PA-CSD)、泊洛沙姆姜黄提取物固体分散体(Poloxamer-CLRE solid dispersion,P-CSD),增加CLRE在水中的溶解度和体外溶出度,改善SD的稳定性和吸湿性。方法 应用溶剂法制备3种SD;采用体外溶出度、吸湿性、稳定性、物相表征考察等方法对CLRE、PAP-CSD、PA-CSD、P-CSD进行体外评价。结果PAP-CSD、PA-CSD、P-CSD 3种SD制备工艺成熟,CLRE均匀分散在SD中。体外评价结果显示,当CLRE与载体比值为1∶10时,制得的SD体外溶出度最好,且混合载体的体外溶出度比泊洛沙姆-188的效果好,混合载体的吸湿性小于共聚维酮单个载体的吸湿性。结论PAP-CSD、PA-CSD、P-CSD能提高CLRE的溶解度和溶出度,且2个载体的联合使用优于单一载体。
[Key word]
[Abstract]
Objective To prepare PVP/VA-Poloxamer-Jianghuang (Curcumae Longae Rhizoma) extract (CLRE) solid dispersion (SD) (PAP-CSD), PVP/VA CLRE solid dispersion (PA-CSD), Poloxamer CLRE solid dispersion (P-CSD), increase the solubility of CLRE in water and the dissolution rate of CLRE in vitro, and improve the stability and hygroscopicity of solid dispersions. Methods For three SDs prepared by solvent method, in vitro evaluation of CLRE, PAP-CSD, PA-CSD and P-CSD were achieved by investigation of in vitro dissolution, hygroscopicity, stability, and phase characterization. Results Three solid dispersion systems: PAP-CSD, PA-CSD and P-CSD were prepared successfully, the CLRE was evenly dispersed in the SD. The results of in vitro evaluation showed that when the ratio of CLRE to carrier was 1:10, the dissolution of the SD was the best. And the dissolution of the mixed carrier was better than that of Poloxamer-188, the hygroscopicity of the mixed carrier was lower than that of the single carrier of PVP/VA. Conclusion PAP-CSD, PA-CSD and P-CSD could improve the solubility and dissolution rate of CLRE, the combination of the two carriers was better than the single carrier.
[中图分类号]
R283.6
[基金项目]
国家自然科学基金面上项目(81473427)