目的 研究香鳞毛蕨Dryopteris fragrans的化学成分。方法 运用硅胶柱色谱、大孔吸附树脂柱色谱、Sephadex LH-20柱色谱及制备型HPLC等方法进行分离纯化，通过核磁共振、质谱等波谱学方法并结合文献对分离得到的化合物进行结构鉴定。结果 从香鳞毛蕨水提物中分离得到6个化合物，分别鉴定为1-丁酰基-2-羟基-4-甲氧基-3-甲基间苯三酚-6-O-β-D-吡喃葡萄糖苷（1）、5，7-二羟基-2-甲基色原酮-7-O-β-D-葡萄糖苷（2）、monnierisides A（3）、异荭草素（4）、荭草素（5）和异牡荆黄素（6）。结论 化合物1为新化合物，命名为绵马苷；化合物2、3、5、6为首次从该植物中分离得到。

Objective To study the chemical constituents from the whole plants of Dryopteris fragrans. Methods The chemical constituents were isolated and purified by silica gel, macroporous adsorption resin, Sephadex LH-20 column chromatography, and preparative HPLC. The structures of the isolated compounds were identified by NMR and MS spectroscopic methods. Results Six compounds were isolated from the aqueous extract of D. fragrans, and identified as 1-butanoyl-2-hydroxy-4-methoxy-3- methylphloroglucinyl-6-O-β-D-glucopyranoside (1), 5,7-dihydroxy-2-methylchromone-7-O-β-D-glucoside (2), monnierisides A (3), isoorientin (4), orientin (5), and isovitexin (6). Conclusion Compound 1 is a new compound, named aspidinoloside, and compounds 2, 3, 5, 6 are isolated from this plant for the first time.

R284.1

国家自然基金面上项目（81774312）