豨莶草作为我国传统中草药，用药历史悠久，临床多用于风湿痹痛的治疗。豨莶草中化学成分类型丰富，主要成分为二萜类、倍半萜类、黄酮类，其二萜类成分历来被认为是主要的药效物质。对其化学成分、药理作用综述的基础上，根据中药质量标志物（quality maker，Q-Marker）理论，从化学成分特有性、成分有效性、可测成分、入血成分4个方面对豨莶草Q-Marker成分进行预测分析，豨莶苷、奇壬醇、豨莶精醇、槲皮素、黄芩苷作为豨莶草的Q-Marker，为豨莶草制定科学的质量标准提供依据。

As a traditional Chinese herbal medicine in our country, Xixiancao (Siegesbeckiae Herba) has a long history of medication, and it is mostly used in the treatment of rheumatism and pain. There are many types of chemical constituents in the Siegesbeckiae Herba. The main components are diterpenes, sesquiterpenes and flavonoids, and the diterpenoids have always been regarded as the main medicinal substances. Based on the review of its chemical composition and pharmacological effects, and the Q-Markers of Siegesbeckiae Herba in terms of component specificity, constituent validity, component measurability and component absorbed into blood based on the concept of the Q-Marker of traditional Chinese medicine were predicted, which provides a basis for clarifying the Q-Marker and the scientific quality standards of Siegesbeckiae Herba.

R286

河北省自然科学基金资助项目（H2019423050）