红曲为大米接种红曲菌发酵而成，能产生莫纳可林类、甾醇类、红曲色素等多种代谢产物，具有调脂、抗肿瘤、抗氧化、抗糖尿病等生物活性，广泛应用于医药、食品添加剂、发酵食品、生物催化等领域。主要综述了国内外红曲的化学成分、药理作用及临床应用的研究进展，以期为红曲进一步的应用与开发提供参考。

Hongqu (Fermentum Rubrum) is fermented from rice inoculated with monascus fungus, and it can produce many kinds of metabolites such as monacolins, sterols and monascus pigment. It has lipid-regulating, antitumor, antioxidant, antidiabetic effects and other biological activities, and is widely used in medicine, food additives, fermented food, biocatalysis and other fields. Research progress on chemical constituents, pharmacological action and clinical application of Fermentum Rubrum were summarized in this paper, in order to provide reference for further application and development of Fermentum Rubrum.

R282.710.5

国家重大新药创制专项（2019ZX09201005-001-002）；国家中医药管理局中药国际化专项（0610-2040NF020928）