槲皮素是一种多羟基黄酮类化合物，广泛存在于多种药用植物中，具有抗氧化、抗病毒、抗菌、抗炎和抗肿瘤等多种药理作用。分析了近10年国内外有关槲皮素及衍生物防治肝损伤方面的文献，发现其对各种急、慢性肝损伤均具有良好的防治作用，其作用机制主要涉及抗氧化、抗炎、调节脂质代谢、抗凋亡及自噬、抗病毒等。主要对槲皮素及其衍生物防治不同类型肝损伤的作用及机制进行综述，以期为槲皮素保肝作用的深入研究提供较为全面的文献信息支持。

Quercetin is a kind of polyhydroxylated flavone compounds, which is widely found in a variety of medicinal plants. It has multiple biological functions, such as antioxidant, antiviral, antibacterial, anti-inflammatory and anti-tumor activities, etc. By searching the literatures about quercetin and its derivatives on prevention and treatment of liver injury in the past ten years, quercetin and its derivatives were found that they were good remedy for various acute and chronic liver injuries, and their mechanism of action mainly involved anti-oxidation, anti-inflammation, regulation of lipid metabolism, anti-apoptosis, autophagy and anti-virus, etc. Research progress on quercetin and its derivatives in prevention and treatment of different types of liver injury were reviewed in this paper, so as to provide comprehensive literature information support for in-depth study on hepatoprotective effect of quercetin.

R282.710.5

国家自然科学基金资助项目（81960748）