目的 对淫羊藿苷相关的文献数据进行分析，挖掘淫羊藿苷的研究热点和未来研究方向。方法 通过R语言和VOSviewer软件对Web of Science数据库核心集中淫羊藿苷的研究性和综述文献进行计量学分析，结果以可视化形式呈现，分析该领域年发文量趋势、国家机构间合作和未来研究热点。结果 共检索到1060篇文献，2012—2021年发文量占比81.69%，主要集中在以中国为主的亚洲国家，且各国之间合作密切。机构发文量分析显示复旦大学发文量最多达52篇，接收文章最多的期刊为Molecular Medicine Reports和Molecules，均为28篇。关键词演化分析表明淫羊藿苷的研究主要集中在抗炎、抗氧化、抗凋亡等机制和信号通路方面。随着中医药学和多学科的交叉融合发展，尤其以先进药物递送系统为基础改善淫羊藿苷水溶性差等问题将成为未来热点研究领域。结论 淫羊藿苷的年发文量呈递增趋势，主要研究机构分布在国内多个高校和科研院所。以分子生物学技术深入解析淫羊藿苷的药理作用机制，通过化学修饰和制剂学手段改善和提高淫羊藿苷的药效学将为淫羊藿苷的应用提供理论依据和解决方案。对从事淫羊藿苷研究的科研人员具有重要的参考价值。

Objective To analyze a large number of literature data related to icariin and explore the research hotspots and future research directions of icariin. Methods Through R language and VOSviewer software, the articles and reviews about icariin download from the core of the Web of Science database were used for bibliometric analysis, and the results were presented in a visual form to analyze the trend of annual publication volume in this field, cooperation between countries and institutions, and future research hotspots. Results A total of 1060 articles were retrieved. The number of articles published from 2012 to 2021 accounted for 81.69% of the total, mainly in Asian countries dominated by China, with close cooperation among countries. The number of articles published by the institution showed that Fudan University had published a maximum of 52 articles, and the journal that received the most articles were Molecular Medicine Reports and Molecules, both 28 articles. Key words evolution indicated that the research of icariin mainly focused on anti-inflammatory, anti-oxidant, anti-apoptotic and signal pathway research. With the integration and development of traditional Chinese medicine and multi-discipline, especially the improvement of the poor water solubility of icariin based on advanced drug delivery systems will become a hot research area in the future. Conclusion The annual publication volume of icariin showed an increasing trend, and the main research institutions were distributed in many domestic universities and research institutes. In-depth analysis of the pharmacological mechanism of icariin with molecular biology technology, and improvement and enhancement of the pharmacodynamics of icariin through chemical modification and preparation methods will provide theoretical basis and solutions for the application of icariin. This has important reference value for researchers engaged in the research of icariin.

R284;R283

国家自然科学基金青年科学基金项目（82104399）