巴豆Crotonis Fructus是我国传统中药材，也是大毒中药，误用容易造成极大危害。巴豆化学成分复杂多样，包括挥发油、二萜、有机酸、蛋白质、生物碱、甾醇以及微量元素等成分。近年来，随着国内外学者研究的逐渐深入，巴豆在抑菌、抗癌等方面显示出特殊疗效，其新的化学成分与药理活性也不断被发现。在对巴豆资源、化学成分和主要药理活性总结的基础之上，结合质量标志物概念，从巴豆化学成分与其特异性、可测性和中药毒效性的相关性等方面进行质量标志物（quality maker，Q-Marker）的预测分析，建议进一步聚焦巴豆二萜类和蛋白质成分化学物质组的研究分析，为明确巴豆质量标志物，建立科学的巴豆质量评价体系提供依据。

As a kind of traditional Chinese medicinal material, Badou (Crotonis Fructus) also has very strong toxicity. Misuse of Crotonis Fructus can cause great harm easily. Crotonis Fructus contains complex and varied chemical compositions, including volatile oil, diterpenoids, organic acids, proteins, alkaloids, sterols and trace elements. In recent years, with the further study by domestic and foreign scholars, Crotonis Fructus has shown special efficacy in antibacterial, anticancer and other aspects, and its new chemical components and pharmacological activities have been continuously found. Based on the summary of its resources, chemical composition and pharmacological effects, combined with the concept of Q-Marker, this study has processed predictive analysis on Q-Marker from the correlation of the chemical compositions with the specificity, measurability and toxicity of Chinese materia medica. It is suggested that the further research of the chemical group of diterpenoids and proteins should be focused, which could provide basis for clarifying the quality marker and establishing scientific quality system of Crotonis Fructus.

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国家自然科学基金面上项目（81873083）