目的 采用响应面法结合熵权法优选黄芪药材产地加工与炮制一体化工艺。方法 以黄芪甲苷、毛蕊异黄酮葡萄糖苷、芒柄花苷、毛蕊异黄酮、总黄酮、总多糖、水溶性浸出物为考察指标，以含水量（55%、50%、45%）、发汗时长（1、2、3 d）、揉搓次数（1、2、3次）、干燥温度（45、50、55℃）为考察因素，采用Box-Behnken响应面试验设计优化黄芪的产地加工炮制一体化工艺。结果 黄芪药材产地加工炮制一体化最佳工艺条件为含水量为50%，发汗时长3 d，揉搓次数2次，干燥温度为51℃。结论 优选的工艺简便易行，精确度良好，可用于黄芪产地加工炮制一体化。

Objective To optimize the integrative technology of primary processing for Astragali Radix by response surface methodology combined with entropy weight method. Methods Astragaloside IV, calycosin-7-glucoside, ononin, calycosin, total flavonoids, total polysaccharides, water-soluble extracts were used as the inspection indicators; The water content (55%, 50%, and 45%), diaphoretic time (1, 2, 3 d), kneading times (1, 2, and 3 times), drying temperature (45, 50, and 55℃) as the investigation factors, the Box-Behnken response surface test design was used to optimize the production area of Astragali Radix integrated processing technology. Results Optimum integrative technology of primary processing was as follows:water content of 50%, diaphoretic times of 3 d, kneading times of 2 times, and drying temperature of 51℃. Conclusion The optimized integrative technology of primary processing of Astragali Radix was easy and feasible, with high accuracy, which can be used for integrative technology of primary processing of Astragali Radix.

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国家自然科学基金资助项目（82160750）；国家自然科学基金资助项目（81960713）；甘肃省教育厅产业支撑计划项目（2021CYZC-21)；甘肃省自然科学基金创新基地和人才计划项目（18JR3RA197）；甘肃省中药质量与标准研究重点实验室开放基金（ZYZL18-008）；甘肃省中药制药工艺工程研究中心开放课题（ZYGY202003）；甘肃中医药大学研究生创新基金资助项目（2021CX41）