中医理论认为“脾主运化，为气血之源”；肠道菌群具有营养物质代谢和机体免疫功能，与中医“脾”的运化水谷和抗邪功能相对应。肠道菌群的平衡与否直接反映了中医“脾”的功能状态。系统地总结了脾虚证与肠道菌群的关系，并综述了基于肠道菌群常用补气中药和经典方剂治疗脾虚证的药效物质基础，为从代谢组学和肠道菌群角度研究补气中药治疗脾虚的作用机制及靶点奠定基础。

According to the theory of traditional Chinese medicine (TCM), "spleen governs transportation and transformation and is the source of qi and blood"; Intestinal flora has nutrient metabolism and immune function, which is corresponding to the function of "spleen" in TCM to transport water and grain and fight evil. The balance of intestinal flora directly reflects the function of spleen in TCM. The relationship between spleen deficiency syndrome and intestinal flora was systematically summarized in this paper, and the pharmacodynamic substance basis of commonly used qi-tonifying TCMs and classical prescriptions for the treatment of spleen deficiency syndrome based on intestinal flora were summarized, which laid a foundation for the study of mechanism of action and target of qi-tonifying TCMs for the treatment of spleen deficiency from the perspective of metabolomics and intestinal flora.

R282.710.5

国家重点研发计划项目（2017YFC1702105）；吉林省科技发展计划项目（20200201141JC）；吉林省科技发展计划项目（20200404041YY）；2021年度长春中医药大学研究生“橘井杯”学术科研创新及创业项目科学技术类重点项目（ZK202105）