[关键词]
[摘要]
阿魏是一种传统的药用资源,在我国已有1300多年的药用历史,其味苦、辛,性温,具有消积化癥、散痞杀虫等功效。现代研究表明,阿魏中特征性成分主要为倍半萜类、香豆素类、挥发油类等,具有抗炎、抗肿瘤、抗氧化等多种药理活性。近年来,由于环境恶化、过度开采等原因,阿魏野生资源濒临灭绝,市场上阿魏伪品、次品滥用情况时有发生。通过系统查阅文献,结合本课题组的研究工作,对阿魏进行本草考证,总结阿魏属药用植物药效物质基础和药理活性的研究进展,探索传统中药阿魏的质量控制方法、新用途和中药创新药研究方向,对其合理化利用提供新的思路。
[Key word]
[Abstract]
Awei (Ferulae Resina) is a traditional medicinal resource in China, which has a medicinal history more than 1300 years. It has spicy and pungent taste with warm nature, and has the effects of eliminating indigestion, dissipating mass and killing insects. Modern studies have shown that the characteristic components of Ferulae Resina contain sesquiterpenes, coumarins, and volatile oils, with many pharmacological activities like anti-inflammation, antitumor, and anti-oxidation. In recent years, due to environmental degradation and excessive exploitation, the wild resources of Ferulae Resina are on the verge of extinction. And, there is a serious abuse of counterfeit and defective products of Ferulae Resina in the market. In this paper, through the systematic literature review, combined with research work of the research group, the herbal textual research of Ferulae Resina was conducted, and research progress on effective materials and pharmacological activities of Ferulae Resina were summarized. Meanwhile, the new use, quality control methods and innovative Chinese medicine research direction of Ferulae Resina were also explored, in order to provide some new ideas for its rational utilization.
[中图分类号]
R281.3
[基金项目]
国家自然科学基金资助项目(U1903122);国家自然科学基金资助项目(81872768);兴辽英才人才计划项目(XLYC1807118);沈阳药科大学药品监管科学研究院专项基金资助项目(2021jgkx010)