环烯醚萜类化合物是具有丰富生物活性的重要中药成分，其在炮制过程中常常发生分解与转化，可能影响饮片质量、中药药性与药效。为掌握并合理控制含有该类成分中药炮制过程中影响药性与药效的因素，制定科学的炮制工艺，有效利用炮制环节的生物转化，通过本草考证和检索国内外研究文献，基于环烯醚萜化合物的结构、性质以及分布分析，总结影响环烯醚萜类化合物稳定性因素，梳理炮制前后含有环烯醚萜类化合物中药药性与药效的变化，发现当pH值小于3、温度高于45℃、相对湿度高于45%、未灭活的酶存在和药材含水量较高时均会促使环烯醚萜类成分分解、转化，含该类成分的中药炮制后药性由寒转温，作用由清转补，此改变的物质基础与炮制过程中环烯醚萜苷类成分的分解与转化密切相关。因此，在炒制、炙、蒸煮过程中应以临床用药目的为依据合理控制上述影响因素，以达到增效目的，保证中药质量、临床疗效及用药安全。

Iridoid terpenes are important components of traditional Chinese medicine (TCM) with rich biological activities, and they often decompose and transform during the processing, which may affect the quality of decoction pieces, the properties and efficacy of TCM. In order to master and reasonably control the factors that affect the drug properties and efficacy in the processing of TCM containing iridoid terpenes, scientific processing technology should be formulated, and the biotransformation of processing link should be effectively utilized. Based on the analysis of the structure, properties and distribution of iridoid terpenes, the factors affecting the stability of iridoid terpenes through herbal textual research and retrieval of domestic and foreign research literature were summarized in this paper. Combing the changes of the properties and efficacy of TCM containing iridoid terpenes before and after processing, it was found that when the pH value was less than 3, the temperature was higher than 45℃, the relative humidity was higher than 45%, the inactivated enzymes and the high water content of medicinal materials all promoted the decomposition and transformation of iridoid terpenes. After the processing of TCM containing iridoid terpenes, the properties changed from cold to warm, and the action changed from clearing to tonifying. The material basis of this change is closely related to the decomposition and transformation of iridoid glycosides in the processing process. Therefore, in the process of stir-frying, steaming, the above influencing factors should be reasonably controlled on the basis of the purpose of clinical use, so as to achieve the purpose of increasing efficiency and ensure the quality, clinical efficacy and safety of TCM.

R283.1

教育部创新团队发展计划项目（IRT_15R55）；陕西省重点研发计划项目（2017ZDXM-SF-017）；陕西省教育厅重点科学研究计划项目（17JS128）；陕西省重点科技创新团队计划项目（2016KCT-24）