目的 探讨血尿安胶囊联合左氧氟沙星治疗女性复发性尿路感染的临床疗效。方法 122例女性复发性尿路感染患者分为对照组60例和治疗组62例。对照组口服左氧氟沙星片（0.3 g/d）；治疗组在对照组基础上，给予血尿安胶囊（4.2 g/d），均连续治疗2周。观察2组临床疗效，比较症状缓解时间、尿细菌培养转阴率及复发率、血清学指标。结果 治疗后，对照组和治疗组的总有效率分别为63.33%、83.87%，两组差异具有统计学意义（P<0.05）；治疗组患者尿路刺激征缓解时间、尿常规恢复正常时间及尿细菌培养转阴率均优于对照组，差异均有统计学意义（P<0.05）；2组患者血清白细胞介素-6（interleukin-6，IL-6）、IL-8、超敏C反应蛋白（high-sensitivity C-reactive protein，hs-CRP）水平均较治疗前显著降低（P<0.05），同时治疗组显著低于对照组（P<0.05）。治疗结束6个月后治疗组的复发率显著低于对照组（1.6%vs 13.3%）。结论 血尿安胶囊联合左氧氟沙星治疗女性复发性尿路感染临床疗效确切，并可降低复发率，促进患者的血清炎症因子水平回落，安全性良好。

Objective To investigate the clinical efficacy of Xueniaoan Capsule (血尿安胶囊) combined with levofloxacin in the treatment of female recurrent urinary tract infections. Methods A total of 122 female patients with recurrent urinary tract infection were randomly divided into control group (n=60) and treatment group (n=62). The patients in the control group took levofloxacin tablets orally (0.3 g/d); On the basis of the control group, the patients in the treatment group were given Xueniaoan Capsule (4.2 g/d). Both groups were continuously treated for two weeks. The clinical efficacy of the two groups was observed, and the time of symptom relief, conversion negative rate of urine bacterial culture and recurrence rate, and serological parameters were compared. Results After treatment, the clinical efficacy of the control group and the treatment group were 63.33% and 83.87%, respectively. There was significant difference between the two groups (P < 0.05). The results showed that the remission and the recovery time of urinary tract irritation and the conversion negative rate of urine bacterial culture in the treatment group were better than those in the control group (P < 0.05). After treatment, the serum levels of interleukin-6 (IL-6), IL-8 and high-sensitivity C-reactive protein (hs-CRP) in the two groups were significantly lower than those before treatment (P < 0.05), while the levels of inflammatory factors in the treatment group were lower than those in the control group, and the difference between the two groups had statistical significance (P < 0.05). The recurrence rate was significantly lower in the treatment group than in the control group (1.6% vs 13.3%) six months after completion of treatment. Conclusion Xueniaoan Capsule combined with levofloxacin is effective in the treatment of female recurrent urinary tract infections, which helps to reduce the recurrence rate, promotes the reduction of serum inflammatory factor levels in patients, with good safety.

R285.64