[关键词]
[摘要]
姜黄首载于《新修本草》,具有破血行气、通经止痛的功效,常见于活血止痛的方剂中,在中国、印度、泰国传统医学被广泛应用,我国主要分布于四川、福建、广东、广西等地区。姜黄来源于姜科植物姜黄Curcuma longa的干燥根茎,主要含有姜黄素类与萜类成分,具有抗凝血、抗炎、抗肿瘤与止痛等药理作用,但姜黄素类成分的生物利用度较低。对姜黄的本草考证、化学成分、药理作用与药动学的研究进展进行归纳总结,并预测姜黄素类成分姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素以及萜类成分芳姜黄酮、姜黄酮、姜黄烯、姜烯等为姜黄的质量标志物(quality marker,Q-Marker),以期为姜黄的质量控制研究提供参考。
[Key word]
[Abstract]
Jianghuang (Curcumae Longae Rhizoma) was first collected in New Revised of Materia Medica. It has the effects of breaking blood stasis and supplementing qi, treating amenorrhea and relieving pain, and is commonly used in prescriptions for promoting blood circulation and relieving pain. Curcumae Longae Rhizoma is widely used as traditional medicine in China, India and Thailand, and mainly distributed in Sichuan, Fujian, Guangdong and Guangxi in China. Curcumae Longae Rhizoma is derived from the dried rhizome of Curcuma longa, and mainly contains curcuminoids and terpenoids. It possesses diverse pharmacologic effects including anticoagulant, anti-inflammatory, anti-tumor and analgesic activities, but exhibits poor bioavailability. Research progress on textual research, chemical composition, pharmacological action and pharmacokinetics of Curcumae Longae Rhizoma in recent years was summarized in this paper. And it is preliminarily determined that curcumin ingredients curcumin, demethoxycurcumin, bisdemethoxycurcumin, and terpenoids ar-turmerone, turmerone, curcumene, and zingiberene are possible Q-markers of Curcumae Longae Rhizoma, in order to provide reference for the quality control research on Curcumae Longae Rhizoma.
[中图分类号]
[基金项目]
广西中药药效研究重点实验室开放课题(20-065-38);中医药国际合作专项(基地类项目)(0610-2040NF020928);中国医学科学院医学与健康科技创新工程项目(2019-I2M-5-020)