[关键词]
[摘要]
广西莪术Curcuma kwangsiensis为广西道地药材,资源丰富,应用广泛。广西莪术的传统功效为行气破血、消积止痛,具有抗血栓、抗肿瘤、抗炎、抗病毒、保肝、抑菌等药理作用,现代研究认为与其传统功效相关的药理作用主要体现在心血管系统和胃肠道系统方面;主要活性成分为倍萜类化合物和二苯基庚烷类化合物。基于广西莪术化学成分和药理作用的研究进展,从药效、药性、化学成分可测性等方面对广西莪术的质量标志物(quality marker,Q-Marker)进行预测分析,初步确定莪术醇、莪术二醇、莪术烯醇、莪术酮、莪术二酮、β-榄香烯、吉马酮、姜黄素、莪术多糖等为其可能的Q-Marker,为广西莪术的质量评价和研究开发提供科学依据。
[Key word]
[Abstract]
Guangxi Ezhu (Curcuma kwangsiensis) is a genuine medicinal material in Guangxi, which is rich in resources and widely used. The traditional efficacy of C. kwangsiensis is promoting qi and breaking blood, eliminating accumulation and relieving pain. It has antithrombotic, antitumor, anti-inflammatory, antiviral, hepatoprotective, bacteriostatic and other pharmacological effects. Modern research shows that the pharmacological effects related to its traditional efficacy are mainly reflected in the cardiovascular system and gastrointestinal system; the main active components are sesquiterpenoids and diphenylheptanes. Based on research progress on chemical constituents and pharmacological effects of C. kwangsiensis, the quality marker (Q-Marker) of C. kwangsiensis from the aspects of efficacy, drug properties and chemical composition measurability are predicted and analyzed in this paper, and it is preliminarily determined that curcumol, curcumadiol; curcumenol, curzerenone, curdione, β-elemene, germacrone, curcumin, curcuma polysaccharide and other ingredients are possible Q-markers, so as to provide scientific basis for the quality evaluation and research and development of C. kwangsiensis.
[中图分类号]
R282.710.5
[基金项目]
中国-东盟传统药物研究国际合作联合实验室建设(二期)新中心建设项目(CICAR2017-Z1);广西科技基地和人才专项(桂科AD191101553);广西创新驱动重大专项(桂科AA181180492);广西创新驱动重大专项(桂科AA192540334);广西中医药大学广西一流学科建设开放课题(2019XK103)