目的 基于R语言数据挖掘平台对现代文献中紧张型头痛（tension-type headache，TTH）的方药信息进行数据挖掘，为TTH的中药治疗提供新思路。方法 计算机检索中国知网、万方、维普、中国生物医学、PubMed、Embase和Cochrane Library共7个国内外数据库，筛选中药治疗TTH的相关文献。采用Excel软件对方药信息进行提取，采用R语言对中药使用频次、相关性、关联度和聚类等方面进行挖掘分析。结果 共提取出中药治疗TTH的306首经验方药，中药共238味，频次共3187次，其中使用频次>100次的药物依次为川芎、白芍、柴胡、甘草、当归和白芷，使用频次>30次的药物以解表药、活血化瘀药、清热药、补虚药、平肝熄风药为主，相关系数较高的前20味药对组合多为补虚药和活血化瘀药，关联分析和聚类分析形成以川芎、白芍、柴胡和当归为基础的核心药物组方。结论 中药治疗TTH以川芎、白芍、柴胡和当归为核心药物组方，在此基础上加入针对风、火、痰、虚、瘀等致病因素的相应中药，临床可取得较好疗效。建议后续研究应更多关注TTH的核心药物组方，开展高质量的随机对照试验，为TTH的临床治疗提供新思路。

Objective To mine the prescription information of tension-type headache (TTH) in modern literature based on R language data mining platform, so as to provide new ideas for traditional Chinese medicine in the treatment of TTH. Methods Seven databases including CNKI, Wanfang, VIP, CBM, PubMed, EMBASE and Cochrane library were searched by computer to screen the related literatures. Excel software was used to extract prescription information, and the R language was used to mine and analyze the frequency, correlation, association and clustering of traditional Chinese medicine. Results A total of 306 empirical prescriptions for TTH were extracted. There were 238 Chinese herbs with a total frequency of 3187 times. Among them, Chuanxiong (Chuanxiong Rhizoma), Baishao (Paeoniae Radix Alba), Chaihu (Bupleuri Radix), Gancao (Glycyrrhizae Radix et Rhizoma), Danggui (Angelicae Sinensis Radix) and Baizhi (Angelicae Dahuricae Radix) were used more frequently than 100 times. The drugs with a frequency of more than 30 times were mainly for relieving exterior symptoms, promoting blood circulation and removing blood stasis, clearing heat, tonifying deficiency, calming liver and wind. The top 20 drug pairs with higher correlation coefficient were with efficacy for tonifying deficiency, promoting blood circulation and removing blood stasis. Through association and clustering analysis, the core prescriptions based on Chuanxiong Rhizoma, Paeoniae Radix Alba, Bupleuri Radix and Angelicae Sinensis Radix were formed. Conclusion Chuanxiong Rhizoma, Paeoniae Radix Alba, Bupleuri Radix and Angelicae Sinensis Radix are the core herbs of traditional Chinese medicine in the treatment of TTH. On this basis, the corresponding medicine for wind, fire, phlegm, deficiency, blood stasis and other pathogenic factors can be added to achieve better clinical efficacy. It is suggested that follow-up studies should pay more attention to the core drug formulation of TTH and carry out high-quality randomized controlled trials to provide new ideas for the clinical treatment of TTH.

R285

国家中医药管理局中医药传承与创新“百千万”人才工程：岐黄学者项目-国家中医药领军人才支持计划（国中医药人教发[2018]12号）；首都卫生发展科研专项（首发2020-2-4173）；中央级公益性科研院所基本科研业务费专项（ZZ13-024-3）