[关键词]
[摘要]
人类免疫缺陷病毒(human immunodeficiency virus,HIV)潜伏是艾滋病无法治愈的主要障碍。针对HIV潜伏的治疗策略之一“shock and kill”,是通过潜伏感染激活剂激活潜伏的HIV使之发生转录,然后与高效抗逆转录病毒疗法(highly active antiretroviral therapy,HAART)联合使用,并结合细胞的自身免疫监视系统,从而实现清除HIV-1病毒潜伏库的目的。这种策略的核心是安全高效、作用机制新颖HIV潜伏激活剂的发现。从结构分类、来源和作用机制对天然产物HIV-1潜伏激活剂的研究进展进行综述。
[Key word]
[Abstract]
Human immunodeficiency virus (HIV) latency is the main obstacle that AIDS cannot be cured. “Shock and kill”, one of the treatment strategies against HIV latency, is to activate latent HIV through a latent activator to make HIV transcribe, and then combine with highly active antiretroviral therapy (HAART) and autoimmune surveillance system to eliminate the whole HIV-1 latency library. The key of this strategy is the discovery of a safe, efficient, and novel HIV latent activator. Research progress on natural product HIV-1 latency reactivation agents are systematically reviewed in this article in terms of structure classification, source and mechanism of action.
[中图分类号]
R282.71
[基金项目]
国家自然科学基金资助项目(31800293);山西科技攻关项目(201603D3113008,2016ZD0504)