毛兰素是石斛中最重要的天然产物之一。从化学结构上看，毛兰素含有2个多酚醚和酚羟基苯环，这2个苯环通过2个饱和的碳原子连接。以往的研究表明毛兰素具有多种药理作用，包括抗氧化、抑制血管生成和抑制肿瘤生长等。其抗肿瘤作用是综合对多种信号途径调控的结果，这些信号途径大部分与诱导肿瘤细胞凋亡（内源性或外源性）相关。此外毛兰素还可以调节活性氧簇（reactive oxygen species，ROS）/c-Jun氨基末端激酶（c-Jun N-terminal kinase，JNK）信号通路。侵袭、迁移和血管生成是毛兰素新发现的作用机制，这些也进一步支持其抗癌特性。主要对毛兰素的提取分离、化学合成和生物活性的研究进展进行了总结，为毛兰素后续的研究、开发和综合利用提供理论基础。

Erianin is one of the most important natural products in plants of Dendrobium. From the view of chemical structure, erianin contains two polymethoxyl ethers/phenolic hydroxyl-bearing phenyl groups linked by two saturated carbons. Historic studies show that erianin has a variety of pharmacological effects, including antioxidant, inhibition of angiogenesis and inhibition of tumor growth. Its anti-tumor effect is the result of its regulation in various signaling pathways, most of which are associated with the induction of tumor cell apoptosis (endogenous or exogenous). In addition, erianin also regulates the reactive oxygen species/c-Jun N-terminal kinase (ROS/JNK) signaling pathway. Invasion, migration and angiogenesis are novel mechanisms of erianin, which further support its anticancer properties. Research progress on extraction and separation, chemical synthesis and biological activity of erianin are summarized in this paper, in order to provide a theoretical basis for the study, development and comprehensive utilization of erianin in the future.

R284.2;R284.3

国家自然科学基金重点项目（81730108）；国家自然科学基金重点项目（81973635）；国家自然科学基金面上项目（82073686）；杭州市“115”引进国（境）外智力项目计划（20200215）；浙江省大学生科技创新活动计划暨新苗人才计划（2020R427063和2020R427065）；杭州师范大学卓越人才计划科研启动基金资助项目（4125C5021920419）；杭州师范大学医学院教学改革项目（4125b30100112）