石杉型三萜类化合物是石松科植物的特征性成分。目前，从各种植物中共分离得到189个石杉型三萜类化合物，分为一般结构和特殊结构2大类型。一般结构石杉型三萜根据环上氧连接官能团的数量多少可以分为二醇类、三醇类和多醇类。特殊结构石杉型三萜主要有三萜苷类、开环类、环氧类、失碳类、D环为五元环类及D/E环顺式骈合类。其中一些成分在抗肿瘤、细胞毒、抑制胆碱酯酶及β位淀粉样前体蛋白裂解酶1、抑制白色念珠菌分泌型天冬氨酸蛋白酶等方面表现出较好的活性。从石杉型三萜类化合物的植物来源、化学结构和生物活性等方面进行综述，为该类化合物的后续研究提供一定的参考。

Serratene triterpenoids are the characteristic constituents of Lycopodiaceae. At present, 189 serratene triterpenoids have been isolated from a variety of plants, which are divided into two types: general structures and special structures. General serratene triterpenes can be divided into diols, triols, and polyols types according to the number of oxygen-linked functional groups on the rings. Serratene triterpenes with special structures mainly include saponin type, ring-opening type, epoxy type, carbon-losing type, D ring being five-membered ring type, and D/E rings being cis-parallel type. Some of these components show good activities in anti-tumor, cytotoxicity, inhibition of cholinesterase and β-position amyloid precursor protein lyase 1, inhibition of Candida albicans secretory aspartic protease, etc. In this paper, the systematic classification, chemical constituents, and biological activities of serratene triterpenoids are summarized, which provides reference values for the further studies of this kind of compounds.

R282.710.5

长沙市科技计划重点项目（kq1801072）