糖尿病肾病是一类由糖尿病引起的慢性肾脏疾病，临床上主要以持续白蛋白尿和（或）肾小球滤过率进行性下降为特征，是糖尿病患者致残和致死的重要原因之一。磷脂酰肌醇3-激酶（phosphatidyl inositol 3-kinase，PI3K）/蛋白激酶B（protein kinase B，PKB/Akt）信号通路是人体内参与细胞的增殖、分化、凋亡等生理活动的经典信号通路，目前，学者们对糖尿病肾病的发生发展以及药物治疗糖尿病肾病的机制进行了广泛的研究，发现PI3K/Akt信号通路在其中占重要地位。阐述了PI3K/Akt信号通路关键靶标与糖尿病肾病的关系，以便明确PI3K/Akt信号通路在糖尿病肾病中发挥的作用机制；对靶向PI3K/Akt信号通路治疗糖尿病肾病的中药进行系统性总结，以期为糖尿病肾病的治疗以及进一步的药物开发提供参考。

Diabetic nephropathy is a type of chronic kidney disease which caused by diabetes. It is clinically characterized by persistent albuminuria or (and) progressive decline in glomerular filtration rate and one of the important causes of disability and death in diabetic patients. Phosphatidyl inositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) signaling pathway is a classic signaling pathway that participates in cell proliferation, differentiation, apoptosis and other physiological activities in the human body. Nowadays, scholars have carried out extensive research on the mechanism of diabetic nephropathy development and drug therapy, and found that PI3K/Akt signaling pathway occupies an important position among them. The relationship between key targets of the PI3K/Akt signaling pathway and diabetic nephropathy was briefly elaborated in this paper, so as to clarify the mechanism of action of the PI3K/Akt signaling pathway in diabetic nephropathy. Traditional Chinese medicine that targets PI3K/Akt signaling pathway to treat diabetic nephropathy was also systematically summarized to provide references for the treatment of diabetic nephropathy and further drug development.

R282.710.5

国家自然科学基金资助项目（81673615）；全国中药特色技术传承人才培训项目（T20194828003）；成都中医药大学校级科研基金资助项目（QNXZ2018018）