目的 探讨血必净注射液治疗重症监护室（ICU）脓毒症患者的临床效果。方法 回顾性选取2017年11月至2019年12月于天津医科大学三中心临床学院ICU住院患者中脓毒症患者100例，依据治疗方法分为对照组（常规性集束化治疗）和治疗组（在常规性集束化治疗的基础上给予血必净注射液治疗），统计分析两组患者的血清甲状腺激素水平、外周炎症因子水平、肝肾功能、心肌标志物、序贯器官衰竭（sequential organ failure assessment，SOFA）评分、急性生理与慢性健康状况II（acute physiology and chronic health evaluation II，APACHE-II）评分、ICU住院时间、28 d病死情况及不良反应情况。结果 两组患者治疗后的血清三碘甲状腺原氨酸（triiodothyronine，T3）、四碘甲状腺原氨酸（tetraiodothyronine，T4）、游离三碘甲状腺原氨酸（free triiodothyronine，FT3）水平均较治疗前明显升高（P<0.05），治疗后治疗组血清T3、T4、FT3水平较对照组明显升高（P<0.05），但两组患者治疗前后血清游离甲状腺素（free thyroxine，FT4）水平差异不显著。两组患者治疗后的血清降钙素原（procalcitonin，PCT）、C-反应蛋白（C-reactive protein，CRP）、天冬氨酸转氨酶（glutamic oxaloacetic transaminase，AST）、丙氨酸转氨酶（alanine aminotransferase，ALT）、尿素氮（urea nitrogen，BUN）、血肌酐（serum creatinine，SCr）、肌酸激酶同工酶（creatine kinase isoenzyme，CK-MB）、肌钙蛋白I（troponin I，cTnI）水平及SOFA评分、APACHE-II评分均较治疗前明显降低（P<0.05）。治疗后，治疗组血清PCT、CRP、AST、ALT、BUN、SCr、CK-MB、cTnI水平及SOFA评分、APACHE-II评分较对照组明显降低（P<0.05）。两组患者均未发生不良反应。治疗组患者的ICU住院时间显著短于对照组（P<0.05），28 d病死率（20.0%）显著低于对照组（28.0%）（P<0.05）。结论ICU脓毒症患者血必净注射液治疗的临床效果显著。

Objective To investigate the clinical efficacy of Xuebijing Injection (血必净注射液) in the treatment of sepsis in ICU. Methods A total of 100 patients with sepsis in ICU of three center Clinical College of Tianjin Medical University from November 2017 to December 2019 were selected retrospectively. According to the treatment methods, they were divided into control group (conventional cluster treatment) and treatment group (given Xuebijing Injection on the basis of conventional cluster treatment). The serum thyroid hormone levels, peripheral inflammatory factor levels, liver and kidney functions, myocardial markers and sequential organ failure assessment (SOFA) scores, acute physiology and chronic health evaluation II (APACHE-Ⅱ) scores, lengths of ICU stay, 28 day mortality and adverse reaction of the two groups were statistically analyzed. Results The serum levels of T3, T4 and FT3 in the treatment group and the control group were significantly increased after treatment (P < 0.05), and the serum levels of T3, T4 and FT3 in the treatment group were significantly increased after treatment than that in the control group (P < 0.05), but there was no significant difference in serum FT4 levels between the two groups before and after treatment (P > 0.05). The serum PCT, CRP, AST, ALT, BUN, SCr, CK-MB, cTnI levels, SOFA score and APACHE-Ⅱ scores in treatment group and control group after the treatment were significantly reduced (P < 0.05). Serum PCT, CRP, AST, ALT, BUN, SCr, CK-MB, cTnI levels and SOFA score, and APACHE-II score were significantly lower in the treatment group compared with the control group (P < 0.05). No adverse reactions occurred in both groups. The length of stay in ICU in the treatment group was significantly shorter than that in the control group (P < 0.05), and the 28d mortality was 20.0% significantly lower than that in the control group 28.0%, (P < 0.05). Conclusion The clinical effect of Xuebijing Injection on sepsis in ICU is significant.

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天津市科技计划项目—重大疾病防治科技重大专项（18ZXDBSY00100）