目的 解析中药复方中抗抑郁中药的宏观属性（四气、五味、归经等）分布规律及中药与现代药理作用机制的相关性。方法 采用数据挖掘的方法对中国知网（CNKI）中关于中药复方抗抑郁的文献进行分析。结果 检索出1018篇文献，整理出163首复方，涉及262味中药，8种现代药理作用机制；通过频数统计、关联分析以及聚类分析，发现起到抗抑郁作用的中药多为苦、辛，温、寒，归肝、脾、心经的中药，且不同时代的用药规律出现明显的差异性，具体表现为明代以前以"肺脾二经"为主，明代后期至现代以"肝脾二经"为主的用药规律。结论 具备抗抑郁作用的中药属性及作用机制具备一定的分布规律，抑郁症可从肝脾论治，且与脑肠轴相关机制关系密切。这为新的抗抑郁药物及其成分的活性筛选以及抗抑郁药物的实验研究提供数据以及方法学参考。

Objective To analyze the distribution law of anti-depressant traditional Chinese medicine, the properties of anti-depressant traditional Chinese medicine, such as four natures, five flavors and meridian tropism, and explore the correlation between anti-depressant traditional Chinese medicine and its pharmacological mechanism. Methods Data mining wer used to analyze literatures related to anti-depressant traditional Chinese medicine compound retrieved from CNKI. Results A total of 1018 literatures were retrieved from CNKI and 163 Chinese herbal formulas were sorted out, involving 262 traditional Chinese medicines and eight pharmacological mechanism. It was found that most traditional Chinese medicine treating depression had the properties of bitter and pungent flavor, cold and warm nature, and covering meridian tropism were liver channel of Foot-Jueyin, spleen channel of Foot-Taiyin and heart channel of Hand-Shaoyin by virtue of frequency statistics, correlation analysis and cluster analysis. The law of medicine had difference in different era, which showed that the meridian tropism of most traditional Chinese medicine used to treat depression were spleen channel of Foot-Taiyin and the lung channel of Hand-Taiyin before the Ming dynasty and it turned to liver channel of Foot-Jueyin after the Ming dynasty until now. Conclusion The above results indicated that traditional Chinese medicine which can treat depression has the distribution law in the properties and pharmacological mechanism, depression can be treated from the liver and spleen, and it is closely related to the pharmacological mechanism of brain-gut axis, which provides data and methodological references for the screening of new medicine, components with anti-depressant activity and experimental research of new medicine.

R285

国家重点研发计划项目（2017YFC1702703）；山东省重点研发计划项目（2016CYJS08A01-1）；山东省自然科学基金项目（ZR2017LH062）；国家中医药管理局中医药古籍文献和特色技术传承专项（GZY-KJS-2020-046，GZY-KJS-2020-027）；山东中医药大学中医典籍传承青年科研创新团队（22202135）