[关键词]
[摘要]
脓毒症是临床危重病患者死亡的常见原因。中药黄芪由于具有补气升阳、托毒排脓的功效,近年来,临床上使用黄芪及其制剂用于脓毒症治疗的报道越来越多,同时黄芪及其活性成分对脓毒症模型动物的干预效果及其机制研究也成为热点。主要从调节免疫功能、改善炎症反应和微循环障碍、改善多器官损伤等角度,综述了黄芪药材及其活性成分在脓毒症的临床治疗和作用机制研究中的研究进展。
[Key word]
[Abstract]
Sepsis is a common cause of death in critically ill patients. Astragali Radix has the effects of tonifying qi, lifting yang, discharging toxin, and expeling pus. In recent years, there are increasingly reports about Astragali Radix and its preparation used in the treatment of sepsis. At the same time, Astragali Radix and its active ingredients have become a hot spot in the research of its intervention effect and mechanism on sepsis model animals. In this paper, the research progress of Astragali Radix and its active components in the clinical treatment and mechanism of sepsis were summarized from the perspectives of regulating immune function, improving inflammatory response and microcirculation disturbance, and improving multi organ injury.
[中图分类号]
R284;R285
[基金项目]
国家自然科学基金项目(21572219);中国科学院“西部青年学者”项目(2018XBZG_XBQNXZ_A_005);中国科学院战略生物资源服务网络计划项目(ZSTH-031)