目前高血压（hypertension，HTN）存在发病率增加、发病年龄前移的现象，可并发多种心脑血管疾病且预后不良；其发病机制与血管内皮损伤及其介导的炎症、血流机械力改变、血管重构有关。血管生物力学变化是本病的早期和关键致病因素，机械性敏感离子通道及其蛋白通过改善细胞膜张力、调节血管张力及收缩力、参与血管重塑等血管生物力学变化影响高血压的病理进程。活血化瘀类中药发挥对高血压患者血流机械力的调控及维持血压平衡作用，临床有多种中成药用于高血压的治疗，具有良好的疗效。通过对机械性敏感离子通道蛋白家族对心血管系统疾病的调控进展及基于机械力调控的活血化瘀中药对高血压治疗机制进行综述，并对活血化瘀类中药通过机械性敏感离子通道干预高血压进程的可行性进行展望，以期为高血压的临床治疗策略提供新的参考。

Hypertension (HTN) has an increased incidence currently combined with advanced age of onset, which can be complicated by a variety of cardiovascular and cerebrovascular diseases and poor prognosis; Its pathogenesis is related to vascular endothelial injury, its mediated inflammation, blood flow mechanical forces changes and vascular remodeling. Vascular biomechanics changes are the early and key pathogenic factors of this disease. Mechanically sensitive ion channels and their proteins affect the pathological process of hypertension by improving cell membrane tension, regulating vascular tension and contractility, and participating in vascular biomechanical changes such as vascular remodeling. Traditional Chinese medicine (TCM) with blood-activating and stasis-resolving efficacy play an important role in regulating the mechanical force of blood flow in patients with hypertension and maintaining the balance of blood pressure. A variety of Chinese patent medicines are clinically used in the treatment of hypertension with good curative effects. This article reviews the progress in the regulation of mechanically sensitive ion channel protein family on cardiovascular diseases and the mechanism of blood-activating and stasis-resolving TCM based on the regulation of mechanical forces on the treatment of hypertension. The feasibility of the blood pressure process intervened by blood-activating and stasis-resolving TCM is expected to provide a new reference for the clinical treatment strategy of hypertension.

R284

国家自然科学基金面上项目（81773997）；泰山学者工程专项经费项目（ts201511107）