[关键词]
[摘要]
目的 研究蓬莱葛Gardneria multiflora枝叶的化学成分。方法 采用硅胶、ODS、Sephadex LH-20和HPLC等色谱方法进行分离纯化，并根据化合物的理化性质及波谱学数据鉴定其化学结构。结果 从蓬莱葛枝叶中分离得到13个生物碱类化合物，分别鉴定为antirhine 4α-oxide（1）、geissoschizol（2）、melosline E（3）、土波台文碱（4）、tubotaiwine N-oxide（5）、pyridinium（6）、melosline B（7）、N-甲基巴婆碱（8）、venoterpine（9）、肉桂酰胺（10）、lyaloside（11）、异长春花苷内酰胺（12）、柯诺辛碱（13）。结论 化合物1～13均为首次从该植物中分离得到。
[Key word]
[Abstract]
Objective To study the chemical constituents of Gardneria multiflora. Methods The chemical constituents were isolated from the total alkaloids of the twigs and leaves of G. multiflora by using silica gel, ODS, Sephadex LH-20, and HPLC chromatographic methods. The chemical structures were identified based on their physical and chemical properties and spectroscopic methods. Results Thirteen alkaloids were isolated and identified as antirhine 4α-oxide (1), geissoschizol (2), melosline E (3), tubotaiwine (4), tubotaiwine N-oxide (5), pyridinium (6), melosline B (7), N-methylasimilobine (8), venoterpine (9), cinnamamide (10), lyaloside (11), strictosamide (12), corynoxine (13), respectively. Conclusion All compounds are obtained from this plant for the first time.
[中图分类号]
R284.1
[基金项目]
国家自然科学基金资助项目（U1801287）；国家自然科学基金资助项目（82073712）；广东省科技计划项目（2018B020207008，2020B1111110004）
