药性理论是中医药理论体系的核心组成部分，也是指导临床使用中药和阐释中药作用机制的重要依据。有着“国老”美誉的甘草，因其药性和缓，是中医方剂中发挥调和作用的首选药物；而素有“将军”之称的大黄，其药性峻烈，虽为泻下良药，使用不当却会对机体造成损伤。大黄-甘草临床配伍应用已有数千年历史，甘草以其“调和”之性缓大黄峻烈之力，不仅可缓和大黄的泻下作用，还能减轻其不良反应。基于药性理论阐释了甘草缓大黄峻烈之性的传统认识，综述了大黄-甘草配伍后的物质基础、药物代谢、肠道动力、水液代谢、肠道菌群及免疫调控的现代研究进展，以期为甘草缓大黄峻烈之性的深入研究提供依据，同时为阐明甘草“调和”之性的科学内涵提供研究思路。

The theory of drug property is a central component of the theoretical system of traditional Chinese medicine (TCM), as well as an essential reference for guiding the clinical application of TCM and dissecting the action and mechanism of TCM. Glycyrrhizae Radix et Rhizoma (GRR), known as “prime minister”, plays a conciliatory role due to its moderate property. Rhei Radix et Rhizoma (RRR) is well-known as “general” with significant purgation effect in TCM. However, the improper use will cause certain damage to the human body for its drastic purgation. GRR-RRR, as a classic purgation herb pair, has been practiced clinically for thousands of years. GRR can alleviate the drastic property of RRR with its powerful “harmony”, which not only alleviate the purgation of RRR, but also reduce its side effects. Based on the property theory of TCM, this paper elucidated the traditional understanding of GRR on alleviating drastic property of RRR. Furthermore, research progress on modern research of material basis, drug metabolism, intestinal motility, water metabolism, intestinal flora and immunoregulatory of the combination of RRR and GRR are summarized to provide scientific basis for the in-depth study of GRR alleviating the drastic purgation of RRR, as well as provide insights for the scientific connotation of “harmony” of GRR.

R282.710.5

国家自然科学基金资助项目（81974525）；2021年陕西省青年科技新星培育计划项目；2020年陕西高校青年创新团队；陕西中医药大学学科创新团队项目（2019-YL10）