人体的免疫功能是维持身体健康的重要生理性功能，在免疫系统的功能受损或低下时，会对人的身体健康产生严重影响。甘草作为一种补益类中药，有补脾益气之功，对人体的免疫功能具有增强作用，在开发成免疫增强新药方面具有独特优势和发展潜力。通过对近期国内外甘草免疫增强作用的相关文献进行收集和整理，从所含化合物的结构特点、分类及药理作用等方面阐述了甘草增强免疫的物质基础，并以甘草的药效成分为基础综述了甘草促进免疫细胞增殖、影响体内细胞因子和抗体水平以及调控相关酶表达等增强免疫的分子机制，以期为免疫增强药物的研发提供新的思路，为甘草免疫作用的进一步研究提供参考。

The immune function of human body is an important physiological function to maintain health. Impaired or poor immune system function have a serious impact on human health. As a kind of tonic traditional Chinese medicine, gancao (Glycyrrhizae Radix et Rhizoma) has the function of tonifying spleen and replenishing qi and enhancing the immune function of human body, which shows unique advantages and development potential in the development of immunopotentiators. In this paper, through the collection and collation of the recent domestic and foreign literatures on the immune enhancement of G. uralensis, the material basis of the function to enhance immunity of G. uralensis was elaborated from the structural characteristics and classification of compounds and pharmacological effects of G. uralensis. Based on the effective components of G. uralensis, the molecular mechanisms were summarized, expected to provide new ideas for the research and development of immune enhancing drugs, and provide reference for further research and discussion of the immune effect of G. uralensis. The molecular mechanisms include promoting the proliferation of immune cells and improving the biological activity, influencing the levels of cytokines and antibodies in the body, and regulating the expression of related enzymes.

R284;R285

国家重点研发计划（2018YFC1706502）