目的 研究宽苞糙苏Phlomis umbrosa var.latibracteata根降三萜类化学成分。方法 用硅胶柱色谱、凝胶柱色谱、以及制备高效液相色谱等多种色谱分离手段进行分离纯化，用有机波谱手段鉴定分离得到的化合物结构。结果 从宽苞糙苏根的95%乙醇提取物中分离得到8个降三萜类化合物，分别鉴定为糙苏醛A （1）、糙苏酮（2）、糙苏四醇A （3）、糙苏四醇B （4）、糙苏六醇A （5）、糙苏六醇B （6）、糙苏六醇C （7）、糙苏六醇D （8）。结论 化合物1为新化合物，化合物3、4、6~8为首次从宽苞糙苏中分离得到的化合物，这些化合物表现出一定的肿瘤细胞抑制活性。

Objective To study the nortriterpenes from the root of Phlomis umbrosa var. latibracteata. Methods The chemical constituents were isolated by repeated column chromatographies (Toyopearl HW-40C and preparative HPLC). The structures were elucidated on the basis of spectral data analysis. Results Eight nortriterpenes were isolated from the 95% ethanol aqueous extract of P. umbrosa var. latibracteata and the structures were identified as phlomisal A (1), phlomisone (2), phlomistetraol A (3), phlomistetraol B (4), phlomishexaol A (5), phlomishexaol B (6), phlomishexaol C (7), and phlomishexaol D (8). Conclusion Compound 1 is a new compound, and compounds 3, 4, 6-8 are isolated from this plant for the first time. All the nortriterpenes display varying degrees of antitumor activities against cancer cells in vitro.

R284.1

河南省高校科技创新人才支持计划（20HASTIT008）；国家自然科学基金-河南联合基金资助项目（U1404831）<