天然来源的降木脂素类化合物，结构类型复杂多样，分布广泛，根据2个苯丙素分子连接方式和连接位置的不同可将降木脂素分为降木脂素和降新木脂素。降木脂素类化合物具有抗肿瘤、抗过敏、抗炎、抗氧化和抗HIV及激素样作用等多种生物活性。主要对天然来源的降木脂素类化合物的结构类型及生物活性进行综述，为降木脂素类化合物的研究开发和应用提供依据。

As a natural source compound, norlignan compounds have complex and diverse structure types with a wide of sources. Norlignan can be divided into norlignan and norneolignan by the difference of connection mode and position of two phenylpropanoid molecules. Norlignan have various biological activities such as anti-tumor, anti-allergy, anti-inflammatory, antioxidant, anti-HIV, and hormone-like effects. This review mainly describes the structure types and biological activities of natural sources of norlignan, providing a basis for the research development and application of norlignan.

R284;R285

湖南省自然科学基金（2020JJ4064）；湖南省教育厅科研项目（20K095）；湖南省科学技术厅重点研发计划项目（2018SK2119）；湖南省药学一流学科开发基金项目（2020YX05）；湖南中医药大学科研基金项目（2019XJJJ003）