目的 揭示挥发油（volatile oil）的挥发规律，探讨介孔二氧化硅350FCP载体材料固化陈皮、青皮挥发油的稳定性。方法 考察二氧化硅系列载体材料对陈皮、青皮挥发油的吸附能力，分析挥发油与载体材料保留率、挥发率的差异，优选最佳的固化比例。绘制挥发油、载体材料固化粉末中挥发油的化学成分随时间变化的挥发曲线，并对化学成分进行聚类，分析其挥发规律。结果 根据吸附率、挥发率等多因素，优选出介孔二氧化硅350FCP载体材料固化挥发油的最佳比例为3∶5。根据挥发性成分的挥发规律，将挥发油中的34个化学成分分为A、B 2类，A类成分挥发较快，B类成分挥发较慢。挥发油经载体材料固化后，其挥发油的释放变得平稳缓慢。结论 介孔二氧化硅350FCP作为载体材料固化陈皮、青皮挥发油，具有稳定缓慢释放的作用，其制备工艺简单、方便，具有较好的应用前景。

Objective To reveal the volatile oil (VO) volatilization law, explore the stability of volatile oil of Chenpi (Citri Reticulatae Pericarpium, CRP) and Qingpi (Citri Reticulatae Pericarpium Viride, CRPV) solidified by silicon dioxide 350FCP carrier material. Methods The adsorption capacity of silica carrier materials to volatile oil was investigated, the difference of retention rate and volatilization rate between the volatile oil and the carrier materials with different proportions was analyzed, and the best curing ratio was optimized. The volatilization curve of the chemical constituents of volatile oil with time was drawn, and the chemical constituents were clustered to analyze their volatilization rule. Results According to many factors such as adsorption rate and volatilization rate, the optimum ratio of silica 350FCP to essential oil (3:5) was optimized. According to the volatilization rule of volatile components, 34 chemical components in the volatile oil were clustered into A and B. The A components volatilized quickly, while the B components volatilized slowly. After curing by carrier material, the release of volatile oil becomed stable and slow. Conclusion The volatile oil cured by silica 350FCP has the effect of stable and slow release. The preparation technology is simple and convenient with good application prospect.

R283.6

江西省重大科技研发专项：中药精油关键技术与中医香疗健康产品研究及产业化（20194ABC28009）；西南医科大学校级科研项目：中药挥发油挥发规律及载体材料固化挥发油的缓释作用研究（2020ZRQNA032）