目的 基于厚朴"发汗"前后多指标质量差异关键属性优化厚朴"发汗"工艺。方法 采用HPLC法同时测定"发汗"厚朴中紫丁香苷、木兰花碱、厚朴苷A、和厚朴酚及厚朴酚含量，采用CRITIC-层次分析法（CRITIC-AHP）复合加权法计算权重系数，多指标综合评分，结合Box-Behnken响应面法考察水煮时间、堆积天数、干燥温度及干燥时间对"发汗"厚朴质量的影响，优选厚朴"发汗"工艺。结果 厚朴较佳发汗工艺为取厚朴药材，沸水水煮2 min，堆积发汗1 d，晾晒7 d后于45℃烘箱内干燥36 h。结论 采用多指标含量测定、CRITIC-AHP复合加权法结合响应面法优厚朴"发汗"工艺，为厚朴产地加工"发汗"工艺考察提供参考。

Objective To optimize the "sweating" process in producing area for Magnoliae Officinalis Cortex (MOC) based on multi-index determinant attributes of quality difference caused by "sweating". Methods A comprehensive multi-index evaluation of the quality of MOC after "sweating" was made. The contents of syringoside, magnolflorine, maglosideA, honokiol, and magnolol in "sweating" MOC were determined by HPLC, the weight coefficients were calculated by CRITIC-AHP composite weighting method. The effects of boiling time, stacking days, drying temperature and time on the quality were investigated by the method of Box-Behnken response surface, and then the optimization was selected. Results The optimal sweating process of MOC was as following:Boil MOC with boiling water for 2 min; Heap them for "sweating" for 1 d; Air-dry them for 7 d and then oven dry them in 45℃ for 36 h. Conclusion This study has optimized the process of "sweating" process of MOC based on multi-index determination, CRITIC-AHP composite weight calculation and Box-Behnken response surface methodology, which provides the references for the "sweating" process in producing area of MOC.

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国家自然科学基金项目青年基金项目（81603300）；中国博士后科学基金面上项目“西部地区博士后人才资助计划”（2020M673569XB）；四川省科技厅项目（2020YJ0370）；国家药品监督管理局中药材质量监测评价重点实验室开放课题（2020NMPA-CDDC03）