目的 研究麻布七Aconitum sinomontanum的化学成分。方法 采用硅胶柱色谱、半制备型高效液相色谱进行分离纯化，通过理化性质及现代波谱技术鉴定化合物的结构。结果 从麻布七的80%乙醇提取物中分离得到3个二萜类生物碱，分别鉴定为1α，11α，15β-trihydroxylatisine（1）、demethylenedelcorine（2）、denudatine（3）。结论 化合物1为新化合物，命名为光翠雀碱B，化合物3为首次从该植物中分离得到。

Objective To investigate the diterpenoid alkaloids from the roots of Aconitum sinomontanum. Methods The 80% ethanol extract from A. sinomontanum was isolated and purified by silica and semi-preparative HPLC column. Then the structures of obtained compounds were identified by physicochemical properties and spectral data. Results Three compounds were isolated and their structures were identified as 1α,11α,15β-trihydroxylatisine (1), demethylenedelcorine (2), and denudatine (3), respectively. Conclusion Compound 1 is a new compound named denudatine B, and compound 3 is isolated from this plant for the first time.

R284.1

陕西中医药大学学科创新团队项目（2019-YL12）