保元汤源于明代魏直所著《博爱心鉴》，为益气温阳之名方。系统综述了保元汤的古代与近现代研究，保元汤虽为临床疗效确切的古代经方，然其药效物质基础仍不明确。根据中药质量标志物（quality marker，Q-marker）"五原则"对保元汤Q-marker进行预测分析，结果提示人参皂苷Rb₁、Re、Rg₁和芒柄花素、甘草酸、甘草苷、黄芪甲苷可作为保元汤的Q-marker。为保元汤的质量属性研究提供参考，助力于保元汤古代经方研究。

Baoyuan Decoction (保元汤), a classical prescription of replenishing qi and warming yang, is contained in the "Boai Xinjian" written by Wei Zhi in the Ming Dynasty. The ancient and modern studies of Baoyuan Decoction were reviewed systematically in this article. Although Baoyuan Decoction is an ancient classic with exact clinical effect, its medicinal material basis is still unclear. According to the "five principles" of Q-marker, the Q-markers of Baoyuan Decoction were predicted and analyzed. The results showed that ginsenoside Rb₁, ginsenoside Re, ginsenoside Rg₁, formononetin, glycyrrhizic acid, liquiritin, and astragaloside A could be used as the Q-markers of Baoyuan Decoction, which provides a reference for the study of the quality attribute of Baoyuan Decoction, and helps the study of the ancient classical prescriptions of Baoyuan Decoction.

R283.661

国家自然科学基金资助项目（81874344）；中国博士后科学基金资助项目（2018M640755）；湖南省中医药管理局项目（201811、2019104）；湖南省自然科学基金资助项目（2019JJ40220、2019JJ40172）；长沙市科技计划（kq1907136）