目的 探索银杏叶提取物（ginkgo leaf extracts，GBE）调节高脂血症大鼠模型血脂的有效剂量。方法 SD大鼠随机分为对照组、模型组、DBE（1.2、3.8、12.0、37.9、119.8、378.7 mg/kg）组、非诺贝特（20 mg/kg）组。除对照组，其余大鼠以高脂饲料饲养1周建立高脂血症大鼠模型。除对照组和模型组，其余各组大鼠ig相应药物，1次/d，连续6周。每2周检测大鼠血清中三酰甘油（triglycerides，TG）、总胆固醇（total cholesterol，TC）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）和高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）水平。结果 给予GBE 2、4、6周后对大鼠调血脂的最低有效剂量分别为37.9、12.0、3.8 mg/kg；给予GBE（119.8、378.7 mg/kg）4、6周后对大鼠的调血脂作用无显著差异。结论 GBE用于短期治疗高脂血症的有效剂量为37.9~119.8 mg/kg（相当60 kg成人每天用量为377.6~1 193.3 mg），用于预防或保健作用的最低剂量为3.8 mg/kg（相当60 kg成人每天用量为37.8 mg）。

Objective To study the effective dosages of ginkgo leaf extracts(GBE)on regulating blood lipid of hyperlipidemia rats. Methods SD rats were randomly divided into control group, model group, GBE (1.2, 3.8, 12.0, 37.9, 119.8, 378.7 mg/kg) group and fenofibrate (20 mg/kg) group. Rats were feed with high-fat diet for one week to establish hyperlipidemia model except control group. Rats were igadministrated corresponding drugs except control and model group, once daily for six week. The levels of triglycerides (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) in serum of rats were measured every two week. Results After being given GBE for 2, 4, 6 weeks, the minimum effective dosages of GBE for regulating blood lipid in rats were 37.9, 12.0 and 3.8 mg/kg, respectively; GBE at dosages of 119.8 mg/kg and 378.7 mg/kg had no significant difference in regulating blood lipid in rats after 4 and 6 weeks,. Conclusion The dosages of GBE in the short-term treatment of hyperlipidemia were 37.9-119.8 mg/kg, which was equivalent to 377.6-1 193.3 mg for 60 kg adults per day), the minimum dose for preventive or health effects was 3.8 mg/kg, which was equivalent to 37.8 mg for 60 kg adults per day).

R285.5