目的 青稞Hordeum vulgare var. nudum可溶性膳食纤维（soluble dietary fiber of Hordeum vulgare var. nudum，HVSDF）对姜黄素的增溶与促吸收作用研究。方法 利用紫外分光光度法（ultraviolet spectrophotometry，UV）比较HV-SDF与姜黄素复配前后姜黄素在体外的溶出速率；利用超高效液相色谱串联三重四级杆质谱仪（UPLC-ESI-MS/MS）测定HV-SDF与姜黄素复配前后大鼠血浆中姜黄素及其葡萄糖醛酸化代谢产物（curcumin glucuronide，Cur-O-glu）的含量。结果 HV-SDF和姜黄素复配物（HV-SDF-Cur）组的姜黄素的体外溶出度达到62.96%，而姜黄素组的体外溶出度只有26.42%，结果表明，HV-SDF复配姜黄素后可使姜黄素的体外累积溶出率明显增高；测定HV-SDF-Cur组大鼠血浆中姜黄素及Cur-O-glu的含量发现，其结果明显高于姜黄素组。结论 HV-SDF与姜黄素复配后可以增加姜黄素的水溶性和生物利用度；同时可为中药难溶活性成分的临床应用提供新思路。

Objective To study the solubilization and absorption-promoting effect of soluble dietary fiber of Hordeum vulgare var. nudum (HV-SDF) on curcumin. Methods The dissolution rate of curcumin and HV-SDF-Cur was compared by ultraviolet spectrophotometry (UV). The content of curcumin and curcumin glucuronide (Cur-O-glu) in rat plasma of curcumin group and HV-SDF-Cur group was determined by ultra high performance liquid chromatography tandem triple quadrupole mass spectrometer (UPLC-ESI-MS/MS). Results Dissolution rate of curcumin in the HV-SDF-Cur group reached 62.96%, while the curcumin group was only 26.42%. The cumulative dissolution rate of curcumin was significantly increased in HV-SDF-Cur group. The content of curcumin and Cur-O-glu in the plasma in the HV-SDF-Cur group was determined to be significantly higher than that of the curcumin group. Conclusion The soluble dietary fiber from H. vulgare var. nudum (HV-SDF) can increase the solubility and bioavailability of curcumin. This study can also provide new ideas for the clinical application of insoluble active ingredients of traditional Chinese medicine.

国家自然科学基金面上项目（82073994）；四川省科技厅科技项目（2020JDJQ0049）；四川省科技厅科技项目（2016KZ0037）；四川省科技厅科技项目（2017NFP0038）；农业部杂粮加工重点实验室开放课题（2019CC02）；成都中医药大学杏林学者学科人才科研提升计划（XSGG2019005）；成都中医药大学杏林学者学科人才科研提升计划（QNXZ2018026）；教育部春晖计划（20191083-127）；四川省中医药管理局中医药开发专项（2018KF001）；四川省科技厅国际合作项目（2018HH0122）；成都市科技局国际科技合作项目（2017-GH02-00054-HZ）